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In this case, the resulting organoids are specific to a particular brain region (cerebral cortex, hypothalamus, midbrain, etc.) (Paca et al., 2015

Relevant to brain tissue, perturbations (increases or decreases) in levels of several metabolites, including those associated with GSH (e.g., glycine), have been reported 25 h post mortem (Gonzalez-Riano et al., 2017)

Methionine and cysteine play roles in glutathione synthesis and recycling

Differential targeting of GSH1 and GSH2 is achieved by multiple transcription initiation: Implications for the compartmentation of glutathione biosynthesis in the Brassicaceae

10.1073/pnas.80.6.1631 85 KhansariN.SpringerG

Despite this complexity, numerous studies have reached conclusions on the intricate process of ASM remodeling, which includes ASM cell proliferation and apoptosis (255, 256), dysregulation Ca2+ homeostasis (257259), excessive production of ECM components like fibronectin and collagen type I that play a role in stimulating the proliferation of human ASM cells (260264), and factors associated with immune cells, airway cells, growth factors, cytokine and inflammatory mediators (263, 265268)
