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The brain is the predominantly affected tissue in FRDA, but damage to cardiac myocytes and pancreatic beta-cells has also been evidenced (Delatycki and Corben, 2012

Thus, folate builds up in the form of 5mTHF (the "methyl trap") and there is less folate in the forms CH 2 -THF and 10f-THF that are the substrates for thymidylate and purine synthesis, respectively

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Rao , Temam Beshir Raru , Sina Rashedi , Mohammad-Mahdi Rashidi , Prateek Rastogi , Azad Rasul , Zubair Ahmed Ratan , Ramin Ravangard , David Laith Rawaf , Reza Rawassizadeh , Rabail Zehra Raza , Iman Razeghian-Jahromi , Elrashdy Moustafa Mohamed Redwan , Giuseppe Remuzzi , Andre M

The Great Cavern: The Great Cave is a natural formation that was used by the Incas for ceremonial purposes

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