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Activation of those genes, in turn, has been shown to extend the lifespan in a wide variety of organisms and to reduce the incidence of age-related diseases, such as diabetes, cancer, immune deficiencies, and cardiovascular disorders (Bordone and Guarente 2005)

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Assessment of glutathione peroxidase activity in liver tissue is a well-established method for evaluating hepatic antioxidant defense mechanisms and resistance to oxidative stress