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In peripheral white adipocytes, PTH and PTHrP stimulate lipolysis via PKA-mediated phosphorylation of HSL and PLIN1 and beiging via the upregulation of thermogenic genes including Ucp1, Dio2 , and Pgc1a (74, 210, 258, 275)

While there is no incidence data specific to cholestatic DILI, a figure of 1.47 per 300,000 can be extrapolated from data reported by Bjrnsson et al

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