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Subsequently, PINK1 recruits Parkin to the OMM and stimulates its E3 ubiquitin ligase activity by phosphorylating ubiquitin at Ser65

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In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway

Co-treatment with cellular antioxidant agents including EUK-134 (6), resveratrol (84), curcumin (9), CoQ10 (90), dimethyl fumerate (DMF) (95), melatonin (64, 159), and -lipotic acid (160, 161), as well as mitochondrially specific antioxidants including Trolox (14), mitoQ (70), Mito-Tempo (87), and elampimide (13, 87), have been demonstrated to reduce or completely abrogate mitochondrial lesions, including lipid peroxidation, intrinsic apoptosis, and impaired ATP production in both in vitro and in vivo rodent models