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Methylated B12: The Key to Vitality in Perimenopausal and Menopausal Women Written and edited by Sarah Bonza MD, MPH, FAAFP, MSCP, DipABLM, NBC-HWC When women enter perimenopause and menopause, energy levels often plummet, brain fog increases, and vitality can feel out of reach

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Titration: There is generally no need for upward titration with B-complex vitamins as one might do with certain drugs, but if a patient is frail or known to react to injections, the provider may choose to start at a lower dose (for example 0.25-0.5 mL) and then increase to 1 mL as tolerated

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ALADIN III Study Group