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DTX-loaded NPs induced higher apoptosis (P value<0.001) in MDA-MB-231 cells (71.52.8%) compared to free DTX (42.33.1%)

Cuproptosis is characterized by mitochondrial impairment resulting from copper interacting with lipoylated components of the tricarboxylic acid (TCA) cycle, leading to proteotoxic stress and targeted cell death
