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For the FOXO4-DRI treatment group, 50 M FOXO4-DRI (MCE, HY-P4157) was added to the glucose-free DMEM (Gibco, Catalog #11966-025) medium, followed by 3 h of oxygen-glucose deprivation (OGD) treatment

Acknowledgements This work was supported by National Natural Science Foundation of China (NSFC, 81671849, 31800691, 21874026), Science and Technology Commission of Shanghai Municipality (18441901000), Ministry of Science and Technology of China (MOST, 2016YFE0132400), the Special Project on Precision Medicine under the National Key R&D Program (2017YFC0906600), and the National Key Research and Development Program of China (2017YFA0505100)

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