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Accordingly, we conclude that substrate release is initiated by retraction of H312 of TM6 D and H85 of TM2 C (Extended Data Figs

NAD + precursor supplementation in human ageing: clinical evidence and knowledge gaps Nature Metabolism , 2025
SASP factors and DAMS create a chronic inflammatory microenvironment that continuously recruits and activates macrophages and NLRP3 inflammasomes (78, 79)

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