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This may potentially be achieved by activating the adenylate cyclase, which may convert ATP to cAMP

Every thaw introduces: Temperature fluctuations Physical stress Potential concentration changes Additional opportunities for contamination Although some peptides tolerate occasional thawing better than others, minimizing freeze-thaw exposure is considered a standard laboratory practice

Best for research protocols using very small per-dose research units

2014 Oct 1;3(10):647-61

Its a story of immense promise that ultimately fell short of the specific, rigorous endpoints required for a commercial drug
