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17 , 90 FMO3 inhibition An additional enzyme involved in TMAO production is FMO3, which catalyzes the final step in TMAO production, so its inhibition initially appears to be a sensible target

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Enhanced TMAO levels can promote the initiation of the NF-B pathway and improve the expression of pro-inflammatory genes, including chemokines, adhesion molecules, and inflammatory cytokines

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