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TAC-operated mice also exhibited other features consistent with cardiac hypertrophy, including significantly increased heart volume (Figure 1F), as well as significant increases in heart weight relative to body weight or tibial length (Figure 1G)

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Nonetheless, many uncertainties and challenges remain, particularly regarding specific ferroptosis pathways, immunometabolic regulation, and clinical translational applications

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However, GLUT3-targeted therapy has limitations in application, including potential neurotoxicity and restrictions imposed by the blood-brain barrier in most treatment scenarios