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Topical use: Yes, widely available in cosmetic serums and creams

Antioxidant-independent ascorbate enhancement of catecholamine-induced contractions of vascular smooth muscle
Eur J Pharm Sci (2020) 152:105450

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Both norepinephrine and epinephrine are stored in synaptic knobs of neurons that secrete it, however, epinephrine is not a mediator at postganglionic sympathetic nerve impulses
