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Several genes of chromosome 21 are directly implicated in oxidative stress, involving Cu, Zn-SOD (SOD1), ETS2 (ETS Proto-Oncogene 2) transcription factor, stress-inducible factor, protein S100, Down syndrome critical region gene 1 (DSCR1), amyloid precursor protein (APP), the -site APP cleaving enzyme 1 (BACE1) (Antonarakis et al

Oncogene 33 , 16701679 (2014)

Meng W., Chao W., Kaiwei Z., Sijia M., Jiajia S., and Shijie X., Bioactive Compounds From Chinese Herbal Plants for Neurological Health: Mechanisms, Pathways, and Functional Food Applications, Frontiers in Nutrition 12, no

Claudins, particularly claudin-5, are crucial for maintaining BBB integrity

Another crucial factor is the ester form of AX