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In macrophages, impaired mitochondrial GSH import destabilizes Fe-S cluster-containing electron transport chain proteins and reduces LPS-induced inflammatory cytokine production

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3g, GS siRNA transfection, which led to more than 60% GS gene silencing, similarly increased the sensitivity of hepatocytes to TNF killing, suggesting that increased GSSG accumulation mechanistically contributed to cellular glutathione imbalance-induced susceptibility to TNF-induced cell death

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Furness, Sebastian G