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While tirzepatide is not primarily eliminated through the kidneys, the gastrointestinal effects of the medication, including potential nausea, vomiting, and diarrhea, could lead to dehydration and electrolyte imbalances that may be particularly problematic in patients with compromised kidney function

Thus, a consistent association between CAN and the presence of silent myocardial ischemia was shown 259in figure 12

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