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During the process, the complement component activates the expression of C3a anaphylatoxin chemotactic receptor (C3AR1) and stimulates chemotaxis and granule enzyme release (GER), as well as superoxide anion production (SAP)

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doi: 10.1016/j.tem.2017.10.011

It has been shown to exert beneficial effects both alone and as an adjunct to standard medical treatment (Allen 2013
