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H.MallmannC

Inactivation of the GPX4, a ferroptosis regulator to alleviate lipid peroxidation, triggers acute renal failure in mice suggesting that genetic mutation to modulate lipid peroxidation plays an important role in the pathological condition [139]

Se has numerous biological functions related to redox signaling, antioxidant defense systems, thyroid hormone metabolism, and humoral and cell-mediated immune responses [94]

Add to that our increasingly fine-tuned understanding of some of the regulated ROS generating systems that produce a significant fraction of the oxidants to be sensed, and it is clear that we CAN begin to construct models for these complex biological networks, but that continued research will be required in order to better understand the redox chemistry underlying vital cell processes
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All statistical analyses were performed using STATA software (version 16.0), and R software (version 4.1.0, R Foundation for Statistical Computing)
