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1,4 Nonclinical models have reported rapid systemic clearance of ALA along with metabolic processing in multiple tissues

Moreover, the PKC pathway gets activated via high ROS levels in hyperglycemia due to the described biochemical mechanisms

gemessen wurden Glutathion, oxidativer Stress, mitochondriale Funktion, Entzndung, Insulinresistenz und krperliche Parameter

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found that cardiac microvascular endothelial cells isolated from T2DM mice exhibited increased expression of pro-ferroptotic genes (Tfrc, Acsl4, Ptgs2), decreased expression of anti-ferroptotic genes (Gpx4, Slc7a11), and elevated lipid peroxidation (MDA, 4-HNE), indicating that hyperglycemia also induces ferroptosis in endothelial cells [97]

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