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This issue is of particular interest because simple in vitro experiments have shown that GSH can rapidly reduce DHA, even in the absence of an enzyme (Fig

In vivo studies using xenograft models confirmed such findings (Ren et al

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These toxicities can affect nearly any organ system but most commonly manifest as dermatologic toxicity, endocrinopathies, and severe autoimmune colitis , which requires prompt recognition and management with systemic corticosteroids