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In humans and L-gulonolactone oxidase mutant mice studies, ascorbate promoted TET2-dependent 5hmC formation allowing normal differentiation while ascorbate or TET2 deficiency allows HSCs to proliferate resulting in leukaemia [140], [141], [142]

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The presented values are based on three biological replicates

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322 MurugaiyanGda CunhaAPAjayAKJollerNGaroLPKumaradevanSet al

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10.1016/j.jgr.2023.10.001 33 KimM

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Although the hormone showed activity, its short half-life made it impractical for therapeutic use

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The flow diagram of the study population is represented in Figure 1

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