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Nobiletin decreased TMAO-induced apoptosis of HUVEC cells and counteracted TMAO-induced HUVEC cell proliferation, which indicates that it has a potential ability to reduce TMAO levels (Yang et al., 2019)

[193] seemingly reflecting an adaptive response to the energy deficit rather than a direct dietary effect on thyroid function

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Bidirectional pathways of modulation of activity also exist for SIRT1 and AMPK

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Reference #18.47a71002.1784361891.8b4f8e1f
