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This ratio remains constant across all degrees of constitutive pigmentation, ranging from the lightest to the darkest complexions and covering the different Fitzpatrick phototypes [8, 9]

Alterations in other melanogenesis-related genes, such as tyrosinase-related proteins (TRPs) and melanocyte-inducing transcription factor (MITF), further contribute to graying

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Cancer 16 , 694707 (2016)

Abstract In plants, exposure to temperature extremes, heavy metal-contaminated soils, drought, air pollutants, and pathogens results in the generation of reactive oxygen species that alter the intracellular redox environment, which in turn influences signaling pathways and cell fate

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