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434 Unfortunately, clinical trials involving decoy ActRIIB led to treatment-related bleeding problems in volunteers, causing their discontinuation as a potential treatment for cachexia (NCT01099761)

In Phase 3 TRIUMPH-4 trials, 33% of participants at the 12 mg dose experienced diarrhea compared to 13.4% on placebo

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After treatment with GLY, the levels of GPX4, Nrf2 and HO-1 were significantly increased, while the protein level of HMGB1 in the model group was significantly decreased

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Chan School of Public Health Vitamin B12 6