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Metabolomics enrichment indicated that SAC modulates the glutathione metabolism pathway by regulating GSH levels, thereby influencing GPX4 stability and activity

Importantly, pharmacological GCL inhibition hindered lymphoma growth in female -MYC mice, suggesting that this treatment holds promise as a therapeutic strategy for female lymphoma/leukemia patients.

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In young adult mice on a high-fat diet, MOTS-c also activated muscle AMPK and increased GLUT4 levels, leading to better glucose uptake in muscle and prevention of fat accumulation

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