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Known as a highly reactive oxygen-containing molecule, ROS is continuously produced by mitochondrial metabolism and eliminated by dedicated antioxidant systems (Zhang et al., 2017)

10.1016/j.dsx.2020.04.015 13

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Tissue and blood collection After 2 months on diet (16 months of age), all mice were fasted overnight (12 h) and then anesthetized through inhalation of isoflurane (5%)

10.1111/jam.12074 25 CeccheriniC.DaniottiS.BearziC.ReI

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