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As illustrated in Figure 3, the functionalization of MSNs with polymers, ligands, and responsive caps enables stimuli-triggered and site-specific drug delivery

Encouragingly, a few drugs capable of targeting metabolic reprogramming to remodel the TME and reverse immunosuppression have now entered clinical studies (NCT02071862, NCT01791595, NCT03414229)

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For example, reduced glutathione helps regenerate vitamin E and vitamin C levels in the body

pylori and enhance the permeability of the bacterial cell membrane, demonstrating excellent antibacterial efficacy

Severity of withdrawal symptomatology in follicular versus luteal quitters: the combined effects of menstrual phase and withdrawal on smoking cessation outcome