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Consult a healthcare provider before beginning any semaglutide protocol to discuss appropriate dosing, potential interactions with other medications, and contraindications that may apply to your specific health situation

Best practice is to lead with the indication that has the strongest coverage pathway

Bioorg Med Chem (2021) 46

Adjustments depend on lab markers and how well your symptoms respond

Some improvement in symptoms may be seen within a few days to a week after starting treatment, but it can take longer for more severe symptoms to resolve

NNMT inhibition doesn't directly affect gut motility, so prolonged GI symptoms suggest an individual sensitivity rather than a universal mechanism