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Low body temperature (hypothermia) is also a warning, as it reflects severe impairment of the body's ability to regulate temperature

These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

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"These symptoms are real, they are common, and they respond well to treatment