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Reduced TCA cycle output in KEAP1 mutant cells can have wide ranging effects beyond immediate use in biosynthesis pathways, it may also impact the activity of KG-dependent deoxygenases, a family of enzymes that regulate signaling, metabolism, and epigenetic modifications (Loenarz and Schofield, 2008)

NF-B has been described as a master regulator of inflammation since it regulates the expression of multiple inflammatory genes

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Other proteins also play important roles in desensitization, including phosphodiesterases, RGS family proteins and A-kinase-anchoring proteins

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This increases the expression of major antioxidant systems, including GSH, glutathione peroxidase, glutathione S-transferases, thioredoxin (Trx), and thioredoxin reductase (TrxR)