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Thirdly, the objective of treating obesity extends beyond weight loss to include the prevention of obesity-related complications and improvements in comorbid conditions, as evidenced by positive changes in cardiometabolic risk factors observed in Phase 3 clinical trials [87]

Of interest, the down-expression of ACC2 results from an epigenetic process linked to histone deacetylation at the ACACB promoter by Sirtuin 1/6 that are activated by high cytosolic NAD + levels associated with enhanced FAO and reduced glucose metabolism

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