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Casciola-Rosen, L

Hawley et al

Beyond this role, lipid droplet accumulation facilitates the recruitment of the E3 ubiquitin ligase MDM2, thus promoting the degradation of the tumor suppressors p53 [22] and Numb [9]

Bastos Maia S, Rolland Souza AS, Costa Caminha MF, Lins da Silva S, Callou Cruz R, Carvalho Dos Santos C, et al

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Interestingly, exposure to hypoxia, which is known to induce dependency on exogenous fatty acids via steroyl-Coa desaturase inhibition [24], also heightened ccRCC cell sensitivity to triacsin C (Fig