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Cell 82, 14771491

Integrating pharmacogenetic data with Therapeutic Drug Monitoring (TDM) is therefore essential to operationalize pharmacogenetic findings, allowing real-time treatment adjustments based on the patients actual exposure to the medication (Ingelman-Sundberg and Molden, 2025)

What has been lacking is an integrated and quantitative understanding of the kinetics of APAP metabolism, of how APAP dosage affects NAPQI synthesis and GSH concentrations in the liver, of how NAC stimulates the synthesis of GSH, and of how the dosage and timing of NAC affect detoxification of NAPQI

[DOI] [PMC free article] [PubMed] [Google Scholar] 311.Rotruck JT

Cells 12: 1640

In addition, the feasibility of PRIT as a CD38-based therapy was confirmed in murine models with excellent tumor-to-normal organ ratios of absorbed dose [129]