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Preclinical research had shown that IDB could cross the bloodbrain barrier and protect neurons from oxidative damage, indicating its direct role in protecting cognitive function [13, 14]

, Cross-reactive immunologic material status affects treatment outcomes in Pompe disease infants

Pyroptosis can be identified by a combination of specific markers, which include TLR4, GSDMD, activation and release of pro-inflammatory IL-1 and IL-18, as well as the activation of cysteinyl aspartate specific proteinases, such as caspase-1, caspase-3, caspase-4, caspase-5, and caspase-11 (125)

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Yang Q, et al