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The first line of evidence refers to experiments showing that systemic [36] or local [37] salsolinol administration elicits conditioned place preference, exerts alcohol-like motivational/sensitization effects [38, 39] and leads to excessive alcohol intake [39]

PMID: 37923932

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Science of the Total Environment
Nature Reviews Drug Discovery 2 , 114, (2003)
Its broad melanocortin receptor profile means it should never be prescribed casually particularly given the skin and pigmentation considerations