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Figure 1 Pharmacodynamic mechanisms Cisplatin modulates several signal transduction pathways involving AKT (v-akt murine thymoma viral oncogene homolog), c-ABL (v-abl Abelson murine leukemia viral oncogene homolog 1), p53, and MAPK (mitogen-activated protein kinase)/JNK (c-Jun NH2-terminal kinase)/ERK (extracellular signal-regulated kinase)

Their aberrant expression and the accumulation of substrates and intermediates can change the level of H 2 S by orders of magnitude, causing abnormal structures or functions in the eyes

doi: 10.3389/fonc.2018.00500

& Reddy, M

Due to its calming and soothing effect, it works well with a variety of skincare products

Seems to be helping