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Although the dismutation of superoxide by SOD2 is a predominant source of H 2 O 2 , there are other reactions that directly generate H 2 O 2 in mitochondria

Based on a comparison of TPM values for WT and rpoS samples (Supplemental Table 2), 27 additional core genes also are considered absolutely RpoS-dependent

doi: 10.1093/pnasnexus/pgad484

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Subsequent studies revealed heightened sensitivity of MM cell lines to ferroptosis, with combined bortezomib and iron chelation exhibiting superior efficacy in suppressing disease progression compared to monotherapy, these findings collectively underscore the critical role of ferroptosis in MM pathogenesis (Figure 3)