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Under these conditions, mitochondria permeabilize, and proapoptotic factors, such as cytochrome c (Cyt C ) and the apoptosis-inducing factor (AIF), are released into the cytosol

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The fixation of the K13 A212T mutation in the parasite population under selection suggests that it is a putative driver of OZ439 resistance

numbers below the panels are the number of participants contributing to the mean) and estimated treatment difference for the percentage change from baseline to week 104 in body weight based on the trial product estimand