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A scoping review in Cureus (2025) added important context: dual-acting agonists like tirzepatide which targets both GLP-1 and GIP receptors produced greater reductions in weight and insulin sensitivity than GLP-1-only agents

In summary, the clinical potential of CAR-M therapy is becoming evident, while targeting key nodes in macrophage polarizationsuch as Furin, PAD4, and PGAM5and their combination with existing therapies like PD-1 inhibitors are opening new avenues for enhancing anti-tumor immune responses

3l) in neutrophils stimulated through plasma membrane receptors, further highlighting the specificity of the inhibitor toward endosomal Munc13-4STX7 binding and eTLR9 activation by CpG

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