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Zinc also regulates the endolysosomal tethering machinery through the HOPS complex, whose VPS18 and VPS41 subunits contain zinc-binding RING domains essential for heterodimer formation and complex stability, which is critical for autophagosomelysosome and endosomelysosome fusion 104

The pQE-30 bacterial expression plasmid of the U46C mutant of human cytosolic GPX4 (c-GPX4) was a generous gift from Professor Hartmut Kuhn (University Medicine Berlin-Charit, Germany)

Magnusson I, Rothman DL, Katz LD, Shulman RG, Shulman GI

Finally, consider whether the underlying hair loss involves mechanisms beyond CXXC5-mediated Wnt suppression

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Keratin known to be a hair superhero helps fight hair fall & forms hair follicles