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One in vivo comparison of GHK versus GHK-Cu in rat experimental wounds found that GHK alone had no effect, and only the copper-bound GHK-Cu form produced a statistically significant increase in collagen accumulation evidence that the copper ion itself, not the peptide backbone alone, may be responsible for much of the collagen-stimulating activity

F., Person, M

Following rSyn-1 treatment, significant improvements were observed in the nanomechanical properties of both the endothelial glycocalyx and the cortical cytoskeleton [40]

& Gonzalez-Perez, O