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Juglanin inhibits NF-B activation induced by IL-1 and also blocks the TLR4/NF-B pathway, significantly reducing pro-inflammatory cytokine production induced by lipopolysaccharide (LPS), and to ameliorate inflammation ( in vivo and in vitro (Khan et al., 2011a)

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It showed anti-proliferation activity of HCT-16 mammalian cells, and increased expression of pro-apoptotic molecules NF-B and p-Akt

ARA-290 appears to modify antigen presentation by dendritic cells to T lymphocytes