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Binding intensities were quantified with FIJI 66 using the microarray profile plugin (OptiNav Inc, Bellevue, WA, USA)

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Illustrative examples of the resolved principle in both ischemia and reperfusion conditions are the studies of BPC 157 therapys effect on severe multiorgan (brain, heart, lung, liver, kidney, and gastrointestinal tract lesions) and vascular failure and occlusion/occlusion-like syndrome [129,130,131,132,133,134,135,136,137,138,139,140,141,142,168]

To further validate cathepsin Bs specific role, we also utilized AAV-mediated overexpression of cathepsin B and its inhibitor cystatin A, which supports our findings