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Metabolism of tissue macrophages in homeostasis and pathology

The potential of a B12 overdose is not very likely, but it is most certainly possible

doi:10.1159/000053183 Kwon DR, Park GY

To our knowledge, vitamin B6 deficiency in association with POEMS syndrome is much rarer than vitamin B12 deficiency in association with POEMS and has only been described in two cases [6]

Why is Vitamin B12 Deficiency Common

But for patients who have done the foundational work diet, movement, sleep, lab optimization and are still hitting a wall with fat metabolism or body composition, it may be a worthwhile piece of the puzzle