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In addition, degenerative disorders in the central nervous system (CNS) can be associated with iron accumulation, due to disorders in its metabolism, that can contribute to the process of oxidative stress, inducing inflammation and neuronal damage [3,4]

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A recent systematic review and meta-analysis highlighted the high global prevalence of diabetic foot ulceration among DPN patients, emphasizing the critical need for early detection and comprehensive management strategies to prevent severe outcomes

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