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Best Pract Res Clin Rheumatol 36(3):101757 Zago BA, Priyadharshini A, Vijayakumar TM (2020) Safety and efficacy of newer biologics DMARDs in the management of rheumatoid arthritis: A systematic review

For example, foamy macrophages in which desmosterol, a cholesterol biosynthetic intermediate, had accumulated, induced many homeostatic responses, including activation of LXR/ gene expression, inhibition of SREBP1 and SERBP2 gene expression, alteration of fatty acid metabolism [131,132,133,134], and suppression of inflammatory response-related gene expression [135]

Second, they found that Sirt1 protein expression is significantly correlated with NNMT expression in hepatocytes [14]

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