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10.1007/s12274-022-4860-y 72 KihmD

Despite the fact that most intracellular Zn is tightly bound to high-affinity Zn-binding proteins such as MT and glutathione (GSH), there is a small pool of free Zn, oscillating from picomolar to low nanomolar concentrations, with central functions as a second messenger in intracellular communication [6,11,21]

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Activation of astrocytes in hippocampus decreases fear memory through adenosine a(1) receptors

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A full list of these adverse effects, as well as other information on the medication class (such as contraindications, toxicity, etc.), can be found on the medications NIH page