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It's all about direct delivery

Administration of a pharmacological necroptosis inhibitor has shown efficacy in reducing astrocyte reactivity and attenuating the loss of dopaminergic neurons and subsequent behavioral deficits in an MPTP model of disease (Qiao et al., 2023)

In experimental research it is used as a tool compound to investigate extracellular matrix modulation, collagen and elastin synthesis, angiogenesis, and gene expression changes in in vitro and in vivo tissue-repair models

Reference: Baar MP et al

For some local diseases related to the skin or nervous system, such as skin nerve injury, local neuropathy, etc., cream formulations can directly deliver drugs to the affected area, increase the concentration of drugs locally, and enhance the therapeutic effect

I am not aware of any formal human study in which this peptide was used, he tells Chemistry World