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Mitochondria are biosynthetic hubs for essential iron cofactors such as iron-sulfur (Fe-S) clusters and heme

For instance, copper deprivation contributes to neogenesis of alpha and beta cells in the pancreatic ducts of diabetic rats [ 42 ]

[DOI] [PMC free article] [PubMed] [Google Scholar] 65.Boon A.C.M., Vos A.P., Graus Y.M.F., Rimmelzwaan G.F., Osterhaus A.D.M.E

46 CuculloL.HossainM.RappE.MandersT.MarchiN.JanigroD

This is particularly relevant for injectable formulations obtained outside standard pharmaceutical channels, where risks of contamination, endotoxin exposure, or improper compounding may exceed any theoretical biologic effect

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