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If you have a fat malabsorption disorder or follow a low fat diet, you may be at an increased risk of vitamin E deficiency

doi: 10.1186/s12953-018-0131-y, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 42.Hollenbach M

doi: 10.3389/fmicb.2018.02233 46 WangZLiYLiaoWHuangJLiuYLiZet al

However, the replacement of selenium with sulfur in the GPX4 variant (red) inclines to facilitate the irreversible overoxidation and resultant inactivation of the enzyme, which could trigger a premature termination of the catalytic cycle before it proceeds into the second (reductive) phase

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